The emerging role of noncoding RNAs in systemic lupus erythematosus: new insights into the master regulators of disease pathogenesis
| Title: | The emerging role of noncoding RNAs in systemic lupus erythematosus: new insights into the master regulators of disease pathogenesis |
|---|---|
| Authors: | Mina Afrashteh Nour, Farid Ghorbaninezhad, Zahra Asadzadeh, Amir Baghbanzadeh, Hamidreza Hassanian, Patrizia Leone, Mahdi Jafarlou, Nazila Alizadeh, Vito Racanelli, Behzad Baradaran |
| Source: | Therapeutic Advances in Chronic Disease, Vol 14 (2023) |
| Publisher Information: | SAGE Publishing, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | Therapeutics. Pharmacology, RM1-950 |
| More Details: | Auto-immune diseases are a form of chronic disorders in which the immune system destroys the body’s cells due to a loss of tolerance to self-antigens. Systemic lupus erythematosus (SLE), identified by the production of autoantibodies in different body parts, is one of the most well-known examples of these diseases. Although the etiology of SLE is unclear, the disease’s progression may be affected by genetic and environmental factors. As studies in twins provide adequate evidence for genetic involvement in the SLE, other phenomena such as metallization, histone modifications, and alterations in the expression of noncoding RNAs (ncRNAs) also indicate the involvement of epigenetic factors in this disease. Among all the epigenetic alterations, ncRNAs appear to have the most crucial contribution to the pathogenesis of SLE. The ncRNAs’ length and size are divided into three main classes: micro RNAs, long noncoding RNAs (LncRNA), and circular RNAs (circRNAs). Accumulating evidence suggests that dysregulations in these ncRNAs contributed to the pathogenesis of SLE. Hence, clarifying the function of these groups of ncRNAs in the pathophysiology of SLE provides a deeper understanding of the disease. It also opens up new opportunities to develop targeted therapies for this disease. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-6231 20406223 |
| Relation: | https://doaj.org/toc/2040-6231 |
| DOI: | 10.1177/20406223231153572 |
| Access URL: | https://doaj.org/article/9560f8efce3b4cc588f4411d5fadfb5a |
| Accession Number: | edsdoj.9560f8efce3b4cc588f4411d5fadfb5a |
| Database: | Directory of Open Access Journals |
| ISSN: | 20406231 20406223 |
|---|---|
| DOI: | 10.1177/20406223231153572 |
| Published in: | Therapeutic Advances in Chronic Disease |
| Language: | English |