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Effect of Total Saponins of Panax Notoginseng on Lipids Deposition of Apolipoprotein E-Knockout Mice

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Title: Effect of Total Saponins of Panax Notoginseng on Lipids Deposition of Apolipoprotein E-Knockout Mice
Authors: Changgeng FU, Ruina BAI, Yue LIU, Linzi LONG, Keji CHEN
Source: 康复学报, Vol 28, Pp 27-31 (2018)
Publisher Information: Editorial Office of Rehabilitation Medicine, 2018.
Publication Year: 2018
Collection: LCC:Medicine
Subject Terms: atherosclerosis, lipid deposition, total saponins of panax notoginseng, apolipoprotein E, knockout, Medicine
More Details: Objective:To study the effect of total saponins of panax notoginseng (PNS) on high-fat diet induced lipids deposition on the aortic tissue of apolipoprotein E-knockout (ApoE-/-) mice.Methods:The atherosclerosis models were prepared with a high-fat diet in the ApoE-/-mouse model for 12 weeks. All ApoE-/-mice were randomly divided into three groups (model group, simvastatin group and total saponins group),and the wild type C57BL/6J mice were taked as the control group. ApoE-/-mice continuely intook high fat feeding by gavage for 8 weeks. Blood and the aortic root tissue were collected and serum lipid level was detected by biochemical analyzer, the serum IL-1β,IL-10 concentration was detected by ELISA, the lipid deposition of aortic tissue was observed by oil red O staining, CD68+macrophage aggregation of aortic tissue was observed by immunohistochemical staining.Results:In the model group, TC and LDL-C were significantly increased, HDL-C was slightly reduced, and IL-1β,IL-10 were also increased significantly (PP68+macrophage was also increased significantly in aortic tissue (all PPP68+macrophage number and the macrophage aggregation were significantly reduced (all P
Document Type: article
File Description: electronic resource
Language: English
Chinese
ISSN: 2096-0328
Relation: http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.03027; https://doaj.org/toc/2096-0328
DOI: 10.3724/SP.J.1329.2018.03027
Access URL: https://doaj.org/article/9553b9746ade4b6eb9ab1ce8953753b7
Accession Number: edsdoj.9553b9746ade4b6eb9ab1ce8953753b7
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  Data: Effect of Total Saponins of Panax Notoginseng on Lipids Deposition of Apolipoprotein E-Knockout Mice
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  Data: <searchLink fieldCode="AR" term="%22Changgeng+FU%22">Changgeng FU</searchLink><br /><searchLink fieldCode="AR" term="%22Ruina+BAI%22">Ruina BAI</searchLink><br /><searchLink fieldCode="AR" term="%22Yue+LIU%22">Yue LIU</searchLink><br /><searchLink fieldCode="AR" term="%22Linzi+LONG%22">Linzi LONG</searchLink><br /><searchLink fieldCode="AR" term="%22Keji+CHEN%22">Keji CHEN</searchLink>
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  Data: 康复学报, Vol 28, Pp 27-31 (2018)
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  Data: Editorial Office of Rehabilitation Medicine, 2018.
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  Data: 2018
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  Data: LCC:Medicine
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  Data: <searchLink fieldCode="DE" term="%22atherosclerosis%22">atherosclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22lipid+deposition%22">lipid deposition</searchLink><br /><searchLink fieldCode="DE" term="%22total+saponins+of+panax+notoginseng%22">total saponins of panax notoginseng</searchLink><br /><searchLink fieldCode="DE" term="%22apolipoprotein+E%22">apolipoprotein E</searchLink><br /><searchLink fieldCode="DE" term="%22knockout%22">knockout</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
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  Label: Description
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  Data: Objective:To study the effect of total saponins of panax notoginseng (PNS) on high-fat diet induced lipids deposition on the aortic tissue of apolipoprotein E-knockout (ApoE-/-) mice.Methods:The atherosclerosis models were prepared with a high-fat diet in the ApoE-/-mouse model for 12 weeks. All ApoE-/-mice were randomly divided into three groups (model group, simvastatin group and total saponins group),and the wild type C57BL/6J mice were taked as the control group. ApoE-/-mice continuely intook high fat feeding by gavage for 8 weeks. Blood and the aortic root tissue were collected and serum lipid level was detected by biochemical analyzer, the serum IL-1β,IL-10 concentration was detected by ELISA, the lipid deposition of aortic tissue was observed by oil red O staining, CD68+macrophage aggregation of aortic tissue was observed by immunohistochemical staining.Results:In the model group, TC and LDL-C were significantly increased, HDL-C was slightly reduced, and IL-1β,IL-10 were also increased significantly (PP68+macrophage was also increased significantly in aortic tissue (all PPP68+macrophage number and the macrophage aggregation were significantly reduced (all P
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  Data: http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.03027; https://doaj.org/toc/2096-0328
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3724/SP.J.1329.2018.03027
    Languages:
      – Text: English
      – Text: Chinese
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 27
    Subjects:
      – SubjectFull: atherosclerosis
        Type: general
      – SubjectFull: lipid deposition
        Type: general
      – SubjectFull: total saponins of panax notoginseng
        Type: general
      – SubjectFull: apolipoprotein E
        Type: general
      – SubjectFull: knockout
        Type: general
      – SubjectFull: Medicine
        Type: general
    Titles:
      – TitleFull: Effect of Total Saponins of Panax Notoginseng on Lipids Deposition of Apolipoprotein E-Knockout Mice
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            NameFull: Changgeng FU
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            NameFull: Ruina BAI
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            NameFull: Yue LIU
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            NameFull: Linzi LONG
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          Name:
            NameFull: Keji CHEN
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              M: 06
              Type: published
              Y: 2018
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              Value: 28
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            – TitleFull: 康复学报
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