Effect of Total Saponins of Panax Notoginseng on Lipids Deposition of Apolipoprotein E-Knockout Mice
| Title: | Effect of Total Saponins of Panax Notoginseng on Lipids Deposition of Apolipoprotein E-Knockout Mice |
|---|---|
| Authors: | Changgeng FU, Ruina BAI, Yue LIU, Linzi LONG, Keji CHEN |
| Source: | 康复学报, Vol 28, Pp 27-31 (2018) |
| Publisher Information: | Editorial Office of Rehabilitation Medicine, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Medicine |
| Subject Terms: | atherosclerosis, lipid deposition, total saponins of panax notoginseng, apolipoprotein E, knockout, Medicine |
| More Details: | Objective:To study the effect of total saponins of panax notoginseng (PNS) on high-fat diet induced lipids deposition on the aortic tissue of apolipoprotein E-knockout (ApoE-/-) mice.Methods:The atherosclerosis models were prepared with a high-fat diet in the ApoE-/-mouse model for 12 weeks. All ApoE-/-mice were randomly divided into three groups (model group, simvastatin group and total saponins group),and the wild type C57BL/6J mice were taked as the control group. ApoE-/-mice continuely intook high fat feeding by gavage for 8 weeks. Blood and the aortic root tissue were collected and serum lipid level was detected by biochemical analyzer, the serum IL-1β,IL-10 concentration was detected by ELISA, the lipid deposition of aortic tissue was observed by oil red O staining, CD68+macrophage aggregation of aortic tissue was observed by immunohistochemical staining.Results:In the model group, TC and LDL-C were significantly increased, HDL-C was slightly reduced, and IL-1β,IL-10 were also increased significantly (PP68+macrophage was also increased significantly in aortic tissue (all PPP68+macrophage number and the macrophage aggregation were significantly reduced (all P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Chinese |
| ISSN: | 2096-0328 |
| Relation: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.03027; https://doaj.org/toc/2096-0328 |
| DOI: | 10.3724/SP.J.1329.2018.03027 |
| Access URL: | https://doaj.org/article/9553b9746ade4b6eb9ab1ce8953753b7 |
| Accession Number: | edsdoj.9553b9746ade4b6eb9ab1ce8953753b7 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20960328 |
|---|---|
| DOI: | 10.3724/SP.J.1329.2018.03027 |
| Published in: | 康复学报 |
| Language: | English Chinese |