Academic Journal
Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease
| Title: | Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease |
|---|---|
| Authors: | Takayuki Kunisato, Mikio Watanabe, Naoya Inoue, Azusa Okada, Takashi Nanba, Wataru Kobayashi, Yuka Inoue, Yuka Katsumata, Naoki Omori, Takayuki Nobuhara, Kazuya Takemura, Yoh Hidaka, Yoshinori Iwatani |
| Source: | Autoimmunity, Vol 51, Iss 7, Pp 360-369 (2018) |
| Publisher Information: | Taylor & Francis Group, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Internal medicine |
| Subject Terms: | th17, single nucleotide polymorphism, intractability, severity, il-17f, Internal medicine, RC31-1245 |
| More Details: | The prognosis of autoimmune thyroid disease (AITD) including Graves’ disease (GD) and Hashimoto’s disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD. However, the association between gene polymorphisms in Th17-related genes and the prognosis of AITD was not clarified. To clarify this association, we genotyped 12 polymorphisms in 11 Th17-related genes (IL1Ra, IL6R, IL17R, IL21R, IL23R, CCR6, SOCS3, RORC, IL17A, IL17F and IL21) in 142 HD patients including 58 patients with severe HD and 48 patients with mild HD, 170 patients with GD including 81 patients with intractable GD and 49 patients with GD in remission, and 84 healthy volunteers. The frequency of the IL17F rs763780 T allele was higher in patients with severe HD than in patients with mild HD (p = .008). The frequency of the IL17R rs9606615 T allele was higher in patients with HD than in normal subjects (p = .011). The frequencies of the SOCS3 rs4969170 AA genotype, CCR6 rs3093024 AA genotype, and IL21 rs907715 AA genotype were higher in patients with intractable GD than in patients with GD in remission (p = .035, p = .002 and p = .030, respectively). In conclusion, IL17R rs9607715 and IL17F rs763780 polymorphisms are associated with the susceptibility and severity of HD, respectively. IL21 rs907715, SOCS3 rs4969170 and CCR6 rs3093024 polymorphisms are associated with the intractability of GD. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0891-6934 1607-842X 08916934 25870173 |
| Relation: | https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X |
| DOI: | 10.1080/08916934.2018.1534963 |
| Access URL: | https://doaj.org/article/a950b972b1024d25870173fac324059d |
| Accession Number: | edsdoj.950b972b1024d25870173fac324059d |
| Database: | Directory of Open Access Journals |
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| ISSN: | 08916934 1607842X 25870173 |
|---|---|
| DOI: | 10.1080/08916934.2018.1534963 |
| Published in: | Autoimmunity |
| Language: | English |