Bibliographic Details
| Title: |
Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age |
| Authors: |
Claudia Campanello, Claudia Mercuri, Maria Derchi, Gianluca Trocchio, Alessandro Consolaro, Roberta Caorsi, Angelo Ravelli, Alessandro Rimini, Maurizio Marasini, Marco Gattorno |
| Source: |
Children, Vol 9, Iss 5, p 583 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
multisystem inflammatory syndrome in children, cardiovascular manifestations, pediatrics, COVID-19, Pediatrics, RJ1-570 |
| More Details: |
Cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus-19 disease is often observed with a high risk of heart failure. The aim is to describe cardiovascular involvement, management and early outcome in MIS-C by comparing cardiovascular manifestations in children younger and older than 6 years old. This retrospective observational study included 25 children with MIS-C, admitted to a single pediatric center between March 2020 and September 2021. The median age was 5 years (13 patients under 6 years and 12 over 6 years); coronary artery abnormalities were observed in 77% of preschoolers, with small and medium aneurysms in half of the cases and two cases of mild ventricular dysfunction. School-age children presented myopericardial involvement with mild to moderate ventricular dysfunction in 67% of cases, and two cases of transient coronary dilatation. There was a significant NT-pro-BNP and inflammatory markers increase in 25 of the patients, and mild elevation of troponin I in 9. All patients were treated with intravenous immunoglobulin and corticosteroids, and 8 with anakinra. None of the patients needed inotropes or intensive care unit admission. Our study shows the frequent cardiovascular involvement in MIS-C with a peculiar distribution, according to different age group: coronary artery anomalies were more frequent in the younger group, and myopericardial disease in the older one. A prompt multitarget, anti-inflammatory therapy could probably contribute to a favorable outcome. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2227-9067 |
| Relation: |
https://www.mdpi.com/2227-9067/9/5/583; https://doaj.org/toc/2227-9067 |
| DOI: |
10.3390/children9050583 |
| Access URL: |
https://doaj.org/article/94d8ec3adaa94c74943dca22db65f1a5 |
| Accession Number: |
edsdoj.94d8ec3adaa94c74943dca22db65f1a5 |
| Database: |
Directory of Open Access Journals |
