Bibliographic Details
| Title: |
Successful treatment of generalized myasthenia gravis with telitacicept: a Chinese case series and literature review |
| Authors: |
Xiaodong Song, Yang He, Hong Jiang, Yao Yu, Yue Sun, Zhaoxu Zhang |
| Source: |
Frontiers in Neurology, Vol 16 (2025) |
| Publisher Information: |
Frontiers Media S.A., 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
generalized myasthenia gravis, telitacicept, B lymphocyte stimulator, a proliferation-inducing ligand, treatment, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
BackgroundDespite existing treatments of generalized myasthenia gravis (gMG), there remains a need for more effective therapies with fewer side effects. Telitacicept, targeting B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), emerges as a potential novel therapy for gMG.Case presentationIn our study, four patients with gMG to standard treatments underwent an 8-week course of telitacicept monotherapy. Post-treatment, all patients exhibited satisfactory improvements. The Myasthenia Gravis Foundation of America Quantitative Myasthenia Gravis (MGFA-QMG) scores, 15-item Myasthenia Gravis Quality of Life (MGQOL-15) scores, and MG-associated Activities of Daily Living (MG-ADL) scores showed a marked reduction, indicating decreased disease severity and enhanced quality of life. Additionally, immunological assessments revealed a decrease in CD19+B lymphocyte counts and acetylcholine receptor (AChR) antibodies. Only one patient reported a mild, transient injection reaction.ConclusionFavorable clinical improvement and mild adverse events for gMG in treated with telitacicept were observed. However, larger-scale and longer-term studies are necessary to confirm these results and fully establish the role of telitacicept in the treatment of gMG. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fneur.2025.1501500/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2025.1501500 |
| Access URL: |
https://doaj.org/article/c94b801a55ee4239be78b6a0877e7756 |
| Accession Number: |
edsdoj.94b801a55ee4239be78b6a0877e7756 |
| Database: |
Directory of Open Access Journals |
