Bibliographic Details
| Title: |
Recent Advances in the Treatment of Genetic Forms of Parkinson’s Disease: Hype or Hope? |
| Authors: |
Francesco Cavallieri, Rubens G. Cury, Thiago Guimarães, Valentina Fioravanti, Sara Grisanti, Jessica Rossi, Edoardo Monfrini, Marialuisa Zedde, Alessio Di Fonzo, Franco Valzania, Elena Moro |
| Source: |
Cells, Vol 12, Iss 5, p 764 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Cytology |
| Subject Terms: |
DJ1, genetic, GBA, LRRK2, Parkinson’s disease, PINK1, Cytology, QH573-671 |
| More Details: |
Parkinson’s disease (PD) is a multifarious neurodegenerative disease. Its pathology is characterized by a prominent early death of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of Lewy bodies with aggregated α-synuclein. Although the α-synuclein pathological aggregation and propagation, induced by several factors, is considered one of the most relevant hypotheses, PD pathogenesis is still a matter of debate. Indeed, environmental factors and genetic predisposition play an important role in PD. Mutations associated with a high risk for PD, usually called monogenic PD, underlie 5% to 10% of all PD cases. However, this percentage tends to increase over time because of the continuous identification of new genes associated with PD. The identification of genetic variants that can cause or increase the risk of PD has also given researchers the possibility to explore new personalized therapies. In this narrative review, we discuss the recent advances in the treatment of genetic forms of PD, focusing on different pathophysiologic aspects and ongoing clinical trials. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/12/5/764; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells12050764 |
| Access URL: |
https://doaj.org/article/947854612330497b9de9d0f86362a744 |
| Accession Number: |
edsdoj.947854612330497b9de9d0f86362a744 |
| Database: |
Directory of Open Access Journals |
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