| Title: |
Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study |
| Authors: |
Anna-Lydia Peschmann, Meinrad Beer, Bettina Ammann, Jens Dreyhaupt, Katharina Kneer, Ambros J. Beer, Christian Beltinger, Daniel Steinbach, Holger Cario, Henning Neubauer |
| Source: |
European Radiology Experimental, Vol 3, Iss 1, Pp 1-10 (2019) |
| Publisher Information: |
SpringerOpen, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| Subject Terms: |
Apparent diffusion coefficient, Diffusion magnetic resonance imaging, Ganglioneuroblastoma, Ganglioneuroma, Neuroblastoma, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| More Details: |
Abstract Background Quantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours. Methods Nineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm2) in addition to standard sequences. All DWI scans were analysed for tumour volume assessment and apparent diffusion coefficient (ADC) calculation. Correlation with tumour pathology and risk factors (bone-marrow metastases, MYCN-amplification and 1p-deletion), therapeutic regime (observation versus chemotherapy) and clinical follow-up was evaluated. Results At baseline, mean ADC in NB was lower than in GNB/GN (0.76 vs. 1.47 × 10−3 mm2/s, p = 0.003). An ADC cutoff ≤ 1.05 identified malignant disease with 100.0% sensitivity (95% confidence interval [CI] 29.2–100.0%) and 93.8% specificity (95% CI 69.8–99.8%). Initial ADC was |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2509-9280 |
| Relation: |
http://link.springer.com/article/10.1186/s41747-019-0087-4; https://doaj.org/toc/2509-9280 |
| DOI: |
10.1186/s41747-019-0087-4 |
| Access URL: |
https://doaj.org/article/9426809a27014eacadb5422b3a2e0e8e |
| Accession Number: |
edsdoj.9426809a27014eacadb5422b3a2e0e8e |
| Database: |
Directory of Open Access Journals |
