Bibliographic Details
| Title: |
mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. |
| Authors: |
Wenlei Bao, Yanfeng Wang, Yuting Fu, Xiaoyang Jia, Jiaxin Li, Nyamtsengel Vangan, Lili Bao, Huifang Hao, Zhigang Wang |
| Source: |
PLoS ONE, Vol 10, Iss 5, p e0125910 (2015) |
| Publisher Information: |
Public Library of Science (PLoS), 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of mTORC1 in flagellin-induced inflammatory response is unknown. The purpose of this study was to examine the role and the mechanism of PI3K/Akt/mTOR pathway in flagellin-induced cytokine expression in mouse macrophages. We observed that flagellin upregulated TNF-α time- and dose-dependently. Flagellin stimulated rapid ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC4420466?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0125910 |
| Access URL: |
https://doaj.org/article/9404b1763c0e4d8e97beff5543b9866d |
| Accession Number: |
edsdoj.9404b1763c0e4d8e97beff5543b9866d |
| Database: |
Directory of Open Access Journals |
