Bibliographic Details
| Title: |
Insulin and bone health in young adults: The mediator role of lean mass. |
| Authors: |
Ana Torres-Costoso, Diana P Pozuelo-Carrascosa, Celia Álvarez-Bueno, Asunción Ferri-Morales, Jose Miota Ibarra, Blanca Notario-Pacheco, Vicente Martínez-Vizcaíno |
| Source: |
PLoS ONE, Vol 12, Iss 3, p e0173874 (2017) |
| Publisher Information: |
Public Library of Science (PLoS), 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
BACKGROUND:The positive relationship between lean mass (LM) and bone health is well known, but a positive association between insulin and LM has also been described. Insulin has some anabolic properties on bone through the stimulation of osteoblast differentiation, yet the role of LM as a confounder or mediator in this relationship remains uncertain. OBJECTIVE:To examine whether the association between insulin levels and bone health is mediated by LM. METHODS:A cross-sectional study was conducted at the Castilla La Mancha University (Spain) involving 466 young adults (113 young men; 19.5±2.3 years). LM and total-body bone mineral content (BMC) were measured by dual energy x-ray absorptiometry, and insulin was measured in fasting serum samples. RESULTS:Young adults with high total LM had higher values of total-body BMC than their peers after controlling for age and sex, this relationship persisted after adjusting for insulin levels (p0.05) as indicated by Sobel test values for indirect effect (z = 4.43; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC5360249?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0173874 |
| Access URL: |
https://doaj.org/article/cd9391bcdee34412bc3caacd90bdf1f6 |
| Accession Number: |
edsdoj.9391bcdee34412bc3caacd90bdf1f6 |
| Database: |
Directory of Open Access Journals |
