Academic Journal
Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model.
| Title: | Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model. |
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| Authors: | Drishya Kurup, Delphine C Malherbe, Christoph Wirblich, Rachael Lambert, Adam J Ronk, Leila Zabihi Diba, Alexander Bukreyev, Matthias J Schnell |
| Source: | PLoS Pathogens, Vol 17, Iss 3, p e1009383 (2021) |
| Publisher Information: | Public Library of Science (PLoS), 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| Subject Terms: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| More Details: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respiratory failure, and death. There is an urgent need for a vaccine to prevent its rapid spread as asymptomatic infections accounting for up to 40% of transmission events. Here we further evaluated an inactivated rabies vectored SARS-CoV-2 S1 vaccine CORAVAX in a Syrian hamster model. CORAVAX adjuvanted with MPLA-AddaVax, a TRL4 agonist, induced high levels of neutralizing antibodies and generated a strong Th1-biased immune response. Vaccinated hamsters were protected from weight loss and viral replication in the lungs and nasal turbinates three days after challenge with SARS-CoV-2. CORAVAX also prevented lung disease, as indicated by the significant reduction in lung pathology. This study highlights CORAVAX as a safe, immunogenic, and efficacious vaccine that warrants further assessment in human trials. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1553-7366 1553-7374 |
| Relation: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009383&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: | 10.1371/journal.ppat.1009383&type=printable |
| DOI: | 10.1371/journal.ppat.1009383 |
| Access URL: | https://doaj.org/article/937cbee1c0c04fdabbcbcd261fb4b432 |
| Accession Number: | edsdoj.937cbee1c0c04fdabbcbcd261fb4b432 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1009383&type=printable |
| Published in: | PLoS Pathogens |
| Language: | English |