Diagnostic importance of cystatin C and creatinine for contrast-induced acute kidney injury
| Title: | Diagnostic importance of cystatin C and creatinine for contrast-induced acute kidney injury |
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| Authors: | Pilčević Dejan, Rančić Nemanja, Jović Zoran, Rabrenović Violeta, Antić Svetlana, Petrović Marijana, Petrović Dejan, Maksić Đoko |
| Source: | Vojnosanitetski Pregled, Vol 78, Iss 3, Pp 337-342 (2021) |
| Publisher Information: | Military Health Department, Ministry of Defance, Serbia, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine (General) |
| Subject Terms: | kidney failure, acute, kidney failure, chronic, coronary angiography, creatinine, cystatin c, Medicine (General), R5-920 |
| More Details: | Background/Aim. Contrast-induced acute kidney injury (CI-AKI) is a common complication after the percutaneous coronary intervention, associated with a prolonged hospital stay, increased medical costs, and risk of adverse clinical outcomes. The aim of this study was to compare changes in levels of serum creatinine (sCr) and cystatin C (sCyC) 24 h after coronary angiography as an early indicator of CI-AKI. Methods. The study included 45 patients with chronic renal failure grade I–III scheduled for coronary angiography. Levels of sCr and sCyC were measured a day before and 24 h after coronary angiography. CI-AKI was defined as a 25% and 10% increase of sCr and sCyC levels from baseline within 24 h from contrast media exposure, in the absence of alternative causes. Results. Mean sCr and sCyC concentra-tions were 86.4 ± 22.6 μmol/L and 1.18 ± 0.52 mg/dL, respectively before contrast administration, and 90.6 ± 24.1 μmol/L and 1.24 ± 0.65 mg/dL, respectively 24 h after contrast media exposure. sCr-based CI-AKI occurred in 4 patients (8.89%) and sCyC-based CI-AKI was detected in 19 patients (42.22%) after the contrast procedure (p < 0.001). Conclusion. sCyC level measured 24 h after contrast media exposure is a more sensitive indicator of CI-AKI than sCR level. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Serbian |
| ISSN: | 0042-8450 2406-0720 |
| Relation: | https://doaj.org/toc/0042-8450; https://doaj.org/toc/2406-0720 |
| DOI: | 10.2298/VSP190418075P |
| Access URL: | https://doaj.org/article/937858d5170d451187130818a07384ea |
| Accession Number: | edsdoj.937858d5170d451187130818a07384ea |
| Database: | Directory of Open Access Journals |
| ISSN: | 00428450 24060720 |
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| DOI: | 10.2298/VSP190418075P |
| Published in: | Vojnosanitetski Pregled |
| Language: | English Serbian |