Bibliographic Details
| Title: |
What Guides Peripheral Immune Cells into the Central Nervous System? |
| Authors: |
Theresa Greiner, Markus Kipp |
| Source: |
Cells, Vol 10, Iss 8, p 2041 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Cytology |
| Subject Terms: |
cuprizone, experimental autoimmune encephalomyelitis, multiple sclerosis, inflammation, Cytology, QH573-671 |
| More Details: |
Multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system (CNS), initially presents with a relapsing-remitting disease course. During this early stage of the disease, leukocytes cross the blood–brain barrier to drive the formation of focal demyelinating plaques. Disease-modifying agents that modulate or suppress the peripheral immune system provide a therapeutic benefit during relapsing-remitting MS (RRMS). The majority of individuals with RRMS ultimately enter a secondary progressive disease stage with a progressive accumulation of neurologic deficits. The cellular and molecular basis for this transition is unclear and the role of inflammation during the secondary progressive disease stage is a subject of intense and controversial debate. In this review article, we discuss the following main hypothesis: during both disease stages, peripheral immune cells are triggered by CNS-intrinsic stimuli to invade the brain parenchyma. Furthermore, we outline the different neuroanatomical routes by which peripheral immune cells might migrate from the periphery into the CNS. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/10/8/2041; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells10082041 |
| Access URL: |
https://doaj.org/article/93471264b04d40749898c59f8a25872e |
| Accession Number: |
edsdoj.93471264b04d40749898c59f8a25872e |
| Database: |
Directory of Open Access Journals |
|
Full text is not displayed to guests. |
Login for full access.
|
