Academic Journal
Cargo-eliminated osteosarcoma-derived small extracellular vesicles mediating competitive cellular uptake for inhibiting pulmonary metastasis of osteosarcoma
| Title: | Cargo-eliminated osteosarcoma-derived small extracellular vesicles mediating competitive cellular uptake for inhibiting pulmonary metastasis of osteosarcoma |
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| Authors: | Shanyi Lin, Longqiang Shu, Yuhang Guo, Ji Yuan, Juntao Zhang, Yang Wang, Yunlong Yang, Ting Yuan |
| Source: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | Tumor derived small extracellular vesicles, Osteosarcoma, Cargo elimination, Lung fibroblast, Pre-metastatic niche, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract Osteosarcoma (OS) derived small extracellular vesicles (OS-sEVs) have been shown to induce the formation of cancer-associated fibroblasts (CAFs), characterized by elevated pro-inflammatory factor expression and enhanced migratory and contractile abilities. These CAFs play a crucial role in priming lung metastasis by orchestrating the pre-metastatic niche (PMN) in the lung. Disrupting the communication between OS-sEVs and lung fibroblasts (LFs) emerges as a potent strategy to hinder OS pulmonary metastasis. Our previously established saponin-mediated cargo-elimination strategy effectively reduces the cancer-promoting ability of tumor-derived small extracellular vesicles (TsEVs) while preserving their inherent targeting capability. In this study, we observed that cargo-eliminated OS-sEVs (CE-sEVs) display minimal pro-tumoral and LFs activation potential, yet retain their ability to target LFs. The uptake of OS-sEVs by LFs can be concentration-dependently suppressed by CE-sEVs, preventing the conversion of LFs into CAFs and thus inhibiting PMN formation and pulmonary metastasis of OS. In summary, this study proposes a potential strategy to prevent LFs activation, PMN formation in the lung, and OS pulmonary metastasis through competitive inhibition of OS-sEVs’ function by CE-sEVs. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-024-02636-9 |
| Access URL: | https://doaj.org/article/933ab30648ef42a69c0087bb163eb04e |
| Accession Number: | edsdoj.933ab30648ef42a69c0087bb163eb04e |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14773155 |
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| DOI: | 10.1186/s12951-024-02636-9 |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |