Academic Journal
Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation
| Title: | Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation |
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| Authors: | Yingjuan Liu, Mun-kit Choy, Sabu Abraham, Gennadiy Tenin, Graeme C. Black, Bernard D. Keavney |
| Source: | Data in Brief, Vol 45, Iss , Pp 108770- (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Science (General) |
| Subject Terms: | Long noncoding RNA, Human heart, Cardiomyocyte differentiation, CRISPR, Time-course, Cardiac development, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390 |
| More Details: | This article presents data concerning STX18-AS1, a long noncoding RNA gene identified from a Genome-wide association study of Atrial Septal Defect (ASD). The data describes its expression patterns in human tissues and functions in regulating cardiomyocyte differentiation in vitro. STX18-AS1 is a lncRNA with a higher abundance in developing tissues, including hearts. Its transcription distribution within the embryonic hearts during key heart septation stages supports STX18-AS1’s association with risk SNPs for ASD. The CRISPR stem cell pool in which STX18-AS1 was knocked down, showed reduced CM differentiation efficiency and lower expression of key cardiac transcriptional factors. This indicated its regulative role in supporting the lineage specification from cardiac mesoderm into cardiac progenitors and cardiomyocytes. These data can benefit the understanding of human embryonic heart developmental biology, and the time-course changes of cardiac transcriptional factors during in vitro cardiomyocyte differentiation from human embryonic stem cells. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3409 90656490 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352340922009738; https://doaj.org/toc/2352-3409 |
| DOI: | 10.1016/j.dib.2022.108770 |
| Access URL: | https://doaj.org/article/930e9065649040389cc5ffaff6f6abda |
| Accession Number: | edsdoj.930e9065649040389cc5ffaff6f6abda |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523409 90656490 |
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| DOI: | 10.1016/j.dib.2022.108770 |
| Published in: | Data in Brief |
| Language: | English |