Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study
| Title: | Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study |
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| Authors: | Isabelle Coste, Philippe Judlin, Jean-Pierre Lepargneur, Sami Bou-Antoun |
| Source: | Obstetrics and Gynecology International, Vol 2012 (2012) |
| Publisher Information: | Hindawi Limited, 2012. |
| Publication Year: | 2012 |
| Collection: | LCC:Gynecology and obstetrics |
| Subject Terms: | Gynecology and obstetrics, RG1-991 |
| More Details: | Objective. This study was performed to evaluate the efficacy and safety of a prebiotic treatment in the balance recovery of the vaginal flora in subjects previously treated for bacterial vaginosis (BV). Study Design. A randomized trial was carried out on 42 subjects with an active prebiotic group compared to a placebo group. The main evaluation criterion was the quantification of the vaginal flora measured by the Nugent score. Secondary criteria included vaginal pH and BV recurrence. Results. After 8 days of treatment, all subjects who received the prebiotic had a normal Nugent score, whereas 33% of the subjects treated with placebo had an intermediate or positive Nugent score. After 16 days of application, a normal Nugent score was maintained in all subjects treated with the prebiotic, whereas in the placebo group 24% of the subjects still had an elevated Nugent score. Moreover, the maintenance of (or reversion to) a normal flora was associated with the maintenance of (or reversion to) physiological pH values. Conclusions. The intravaginal gel treatment improves the recovery of a normal vaginal flora after the treatment of a BV episode, which should warrant a reduction in the risk of further recurrences. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1687-9589 1687-9597 |
| Relation: | https://doaj.org/toc/1687-9589; https://doaj.org/toc/1687-9597 |
| DOI: | 10.1155/2012/147867 |
| Access URL: | https://doaj.org/article/caa92fc01a014ca593cc363332548849 |
| Accession Number: | edsdoj.92fc01a014ca593cc363332548849 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16879589 16879597 |
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| DOI: | 10.1155/2012/147867 |
| Published in: | Obstetrics and Gynecology International |
| Language: | English |