Bibliographic Details
| Title: |
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN |
| Authors: |
Flavia Teodora Ioana Paunas, Kenneth Finne, Sabine Leh, Hans-Peter Marti, Frode Berven, Bjørn Egil Vikse |
| Source: |
BMC Nephrology, Vol 23, Iss 1, Pp 1-10 (2022) |
| Publisher Information: |
BMC, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: |
IgA nephropathy, ESRD, Formalin-fixed paraffin embedded kidney biopsy tissue, Liquid chromatography–tandem mass spectrometry, Proteomic analyses, Tubulointerstitium, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: |
Abstract Background IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated tubulointerstitial molecular markers and mechanisms of progression in IgAN. Methods Based on data from the Norwegian Renal Registry, two groups were included: IgAN patients with (n = 9) or without (n = 18) progression to kidney failure during 10 years of follow-up. Tubulointerstitial tissue without discernible interstitial expansion or pronounced tubular alterations was microdissected, proteome was analysed using tandem mass spectrometry and relative protein abundances were compared between groups. Results Proteome analyses quantified 2562 proteins with at least 2 unique peptides. Of these, 150 proteins had significantly different abundance between progressive and non-progressive IgAN patients, 67 were more abundant and 83 less abundant. Periostin was the protein with the highest fold change between progressive and non-progressive IgAN (fold change 8.75, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2369 |
| Relation: |
https://doaj.org/toc/1471-2369 |
| DOI: |
10.1186/s12882-022-02736-4 |
| Access URL: |
https://doaj.org/article/92fbf6d2dc084ffaa3652de186c74f89 |
| Accession Number: |
edsdoj.92fbf6d2dc084ffaa3652de186c74f89 |
| Database: |
Directory of Open Access Journals |
