| Title: |
Characterization of Change in Cognition Before and After COVID-19 Infection in Essential Workers at Midlife |
| Authors: |
Zennur Sekendiz, Olga Morozova, Melissa A. Carr, Ashley Fontana, Nikhil Mehta, Alina Ali, Eugene Jiang, Tesleem Babalola, Sean A.P. Clouston, Benjamin J. Luft |
| Source: |
American Journal of Medicine Open, Vol 12, Iss , Pp 100076- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Coronavirus disease 2019 (COVID-19), Covid-19 related cognitive decline (CRCD), Executive dysfunction, Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), Postacute sequelae of SARS-CoV-2 (PASC), Medicine |
| More Details: |
Background: Research into COVID-19-related cognitive decline has focused on individuals who are cognitively impaired following hospitalization for COVID-19. Our objective was to determine whether cognitive decline emerged after the onset of COVID-19 and was more pronounced in patients with postacute sequelae of SARS-CoV-2 infection (PASC). Methods: We analyzed longitudinal cognitive data collected during a cohort study of essential workers at midlife that continued through the COVID-19 pandemic. We used longitudinal discontinuity models, a form of causal modeling, to examine the change in cognitive performance among 276 participants with COVID-19 in comparison to contemporaneously-collected information from 217 participants who did not have COVID-19. Cognitive performance across four domains was measured before and after the pandemic. Eligible study participants were those with validated COVID-19 diagnoses who were observed before having a verified COVID-19 infection who survived their initial infection, and for whom post-COVID-19 information was also available. Results: The mean age of the COVID-19 group was 56.0 ± 6.6 years old, while the control group was 58.1 ± 7.3 years old. Longitudinal models indicated a significant decline in cognitive throughput (β = -0.168, P = .001) following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors. Associations were larger in those with more severe COVID-19 and those who reported PASC. Observed changes in throughput were equivalent to 10.6 years of normal aging. Conclusion: Findings from this longitudinal causal modeling study revealed that COVID-19 and PASC appeared to cause clincially relevant cognitive deterioration. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2667-0364 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S266703642400013X; https://doaj.org/toc/2667-0364 |
| DOI: |
10.1016/j.ajmo.2024.100076 |
| Access URL: |
https://doaj.org/article/e9271a1bac3a4592a60989d841f9a094 |
| Accession Number: |
edsdoj.9271a1bac3a4592a60989d841f9a094 |
| Database: |
Directory of Open Access Journals |
