Bibliographic Details
| Title: |
Identifying a critical window of maternal metal exposure for maternal and neonatal thyroid function in China: A cohort study |
| Authors: |
Xu Wang, Xian Sun, Yuqing Zhang, Minjian Chen, Gro Dehli Villanger, Heidi Aase, Yankai Xia |
| Source: |
Environment International, Vol 139, Iss , Pp - (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Environmental sciences |
| Subject Terms: |
Metals, Thyroid stimulating hormone, China, Cohort study, Environmental sciences, GE1-350 |
| More Details: |
Background: China, a developing country, has a particularly serious problem with metal pollution. We evaluated the association of metal exposure during pregnancy with maternal and neonatal thyroid function, and identified the critical window for maternal metal exposure effects on maternal and neonatal thyroid functions. Methods: The maternal urinary concentrations of mercury (Hg), cadmium (Cd), arsenic (As) and cesium (Cs) were determined in pregnant women during their first (n = 389) or third (n = 257) trimesters in a prospective cohort from 2014 to 2015 in Nanjing, China, using an inductively coupled plasma mass spectrometry (ICP-MS) instrument. Maternal serum-free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were measured by electrochemiluminescent microparticle immunoassays in the second and third trimesters. Neonatal TSH levels were detected 72 h after birth. Results: Hg (>0.162 µg/L), Cd (>0.084 µg/L), As (>0.348 µg/L) and Cs (>0.093 µg/L) were detectable in 76.9%, 90.1%, 100% and 100% of maternal urine samples from women in the first trimester of pregnancy. In the multiple adjusted linear regression models, maternal exposures to Hg and Cd in the first trimester were positively associated with maternal TSH levels in the second trimester (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0160-4120 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0160412019341716; https://doaj.org/toc/0160-4120 |
| DOI: |
10.1016/j.envint.2020.105696 |
| Access URL: |
https://doaj.org/article/9245ef047f9f4abdaafb7d6e321d0975 |
| Accession Number: |
edsdoj.9245ef047f9f4abdaafb7d6e321d0975 |
| Database: |
Directory of Open Access Journals |
