| Title: |
Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non–Small Cell Lung Cancer |
| Authors: |
Zhenfang Du, Jinghan Sun, Yunkai Zhang, Nigaerayi Hesilaiti, Qi Xia, Heqing Cui, Na Fan, Xiaofang Xu |
| Source: |
Biomolecules, Vol 13, Iss 2, p 210 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
non–small cell lung cancer, EGFR, structure, targeted therapy, Microbiology, QR1-502 |
| More Details: |
Oncogenic mutations within the EGFR kinase domain are well-established driver mutations in non–small cell lung cancer (NSCLC). Small-molecule tyrosine kinase inhibitors (TKIs) specifically targeting these mutations have improved treatment outcomes for patients with this subtype of NSCLC. The selectivity of these targeted agents is based on the location of the mutations within the exons of the EGFR gene, and grouping mutations based on structural similarities has proved a useful tool for conceptualizing the heterogeneity of TKI response. Structure-based analysis of EGFR mutations has influenced TKI development, and improved structural understanding will inform continued therapeutic development and further improve patient outcomes. In this review, we summarize recent progress on targeted therapy strategies for patients with EGFR-mutant NSCLC based on structure and function analysis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2218-273X |
| Relation: |
https://www.mdpi.com/2218-273X/13/2/210; https://doaj.org/toc/2218-273X |
| DOI: |
10.3390/biom13020210 |
| Access URL: |
https://doaj.org/article/91b82196a5e74dc2a9e3001bd1b6bc1a |
| Accession Number: |
edsdoj.91b82196a5e74dc2a9e3001bd1b6bc1a |
| Database: |
Directory of Open Access Journals |
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