Bibliographic Details
| Title: |
Synthesis, characterization of inclusion compounds of amygdalin with β-cyclodextrin and sod-like activity and cytotoxicity on hela tumor cells |
| Authors: |
Eleonora Marian, Narcis Duteanu, Laura Vicas, Gerlinde Rusu, Tunde Jurca, Mariana Muresan, Otilia Micle, Adriana Corina Hangan, Roxana Liana Stan, Corina Ionescu, Bogdan Sevastre, Emöke Páll |
| Source: |
Arabian Journal of Chemistry, Vol 13, Iss 8, Pp 6828-6837 (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Chemistry |
| Subject Terms: |
Amygdalin, β-cyclodextrin, Inclusion compounds, Free radicals, Cytotoxicity, Chemistry, QD1-999 |
| More Details: |
In this work is presented the synthesis of the inclusion complexes of amygdalin with β-cyclodextrin by three methods: kneading, co-precipitation and freeze drying and their characterization.The inclusion compounds were synthesized using a molar ratio of amygdalin: β-cyclodextrin of 1:1. Synthesized compounds were analyzed by FTIR spectroscopy, X-rays, thermal analysis and the results confirm the formation of inclusion compounds by amygdalin with β-cyclodextrin.The studies carried out have shown the protective effect of amygdalin-β-cyclodextrin compounds obtained by freeze drying, kneading and coprecipitation against free radicals (SOD-like activity in vivo) and the results of in vitro cell cytotoxicity of the compounds on HeLa cell line compared to pure amygdalin. Compound obtained by freeze drying has the best SOD-like activity and cytotoxicity on HeLa tumor cells, so it may be considered as potential therapeutic agent. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1878-5352 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1878535220302410; https://doaj.org/toc/1878-5352 |
| DOI: |
10.1016/j.arabjc.2020.06.035 |
| Access URL: |
https://doaj.org/article/90aa8df98e1d4086ac308338cf07c09f |
| Accession Number: |
edsdoj.90aa8df98e1d4086ac308338cf07c09f |
| Database: |
Directory of Open Access Journals |
