Bibliographic Details
| Title: |
Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype |
| Authors: |
Hiroaki Hori, Mariko Itoh, Mingming Lin, Fuyuko Yoshida, Madoka Niwa, Yuko Hakamata, Mie Matsui, Hiroshi Kunugi, Yoshiharu Kim |
| Source: |
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021) |
| Publisher Information: |
Nature Publishing Group, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Abstract Childhood maltreatment has been associated with greater attention bias to emotional information, but the findings are controversial. Recently, a novel index of attention bias, i.e., attention bias variability (ABV), has been developed to better capture trauma-related attentional dysfunction. However, ABV in relation to childhood trauma has not been studied. Here, we examined the association of childhood maltreatment history with attention bias/ABV in 128 healthy adult women. Different types of childhood maltreatment were assessed with the Childhood Trauma Questionnaire. Attention bias/ABV was measured by the dot-probe task. Possible mechanisms whereby childhood maltreatment affects attention bias/ABV were also explored, focusing on blood proinflammatory markers and the BDNF Val66Met polymorphism. We observed a significant positive correlation between childhood emotional abuse and ABV (P = 0.002). Serum high-sensitivity tumor necrosis factor-α levels were significantly positively correlated with ABV (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2158-3188 |
| Relation: |
https://doaj.org/toc/2158-3188 |
| DOI: |
10.1038/s41398-021-01247-4 |
| Access URL: |
https://doaj.org/article/ee904d7c1c8e4a74b5d506987e2e6459 |
| Accession Number: |
edsdoj.904d7c1c8e4a74b5d506987e2e6459 |
| Database: |
Directory of Open Access Journals |
