HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE
| Title: | HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE |
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| Authors: | Izabela Rangel LIMA, Ivanise Brito SILVA, Roberta M Leite LIMA, Tainá M Santos SILVA, Maria B Sousa MAIA, Sônia Pereira LEITE |
| Source: | Arquivos de Gastroenterologia, Vol 56, Iss 4, Pp 333-338 (2019) |
| Publisher Information: | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE), 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Chemical and drug induced liver injury, Indigofera, drug effects, Antioxidants, Acetaminophen, Mice, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | ABSTRACT BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes. Several biological properties, such as anti-inflammatory, anticancer, antitumor, hepatoprotective and low toxicity, are reported for this plant. OBJECTIVE: This study investigated hepatoprotective activity and the antioxidant effect of methanolic extract of I. suffruticosa leaves (MEIS) on Swiss albino mice submitted to experimental models of acetaminophen-induced liver injury. METHODS: MEIS (50 mg/kg; p.o.) was standardized according to the LD50 and its hepatoprotective property on Swiss albino mice evaluated during a 7-day period. On the eighth day, the acetaminophen-induced hepatic injury was performed. Histomorphometric analysis of liver tissue, antioxidant activity and serum levels of alanine aminotransferase (AST), aspartate aminotransferase (ALT) and bilirubin were measured. RESULTS: MEIS (50 mg/kg; p.o.) restored serum enzyme levels and results were close to those of positive control (silymarin) when compared to the negative control. Histopathological and histomorphometric analyzes confirmed MEIS hepatoprotective activity, showing reorganization of structural units of cells, nuclei and sinusoidal capillaries of hepatocytes, reducing the damage on liver tissue and increasing organ regeneration rate. MEIS showed high antioxidant potential at concentrations of 1000 and 500 µg/mL. CONCLUSION: This study suggests that MEIS has hepatoprotective activity and high antioxidant potential. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1678-4219 0004-2803 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019000400333&tlng=en; http://www.scielo.br/pdf/ag/v56n4/1678-4219-ag-s0004280320190000062.pdf; https://doaj.org/toc/1678-4219 |
| DOI: | 10.1590/s0004-2803.201900000-62 |
| Access URL: | https://doaj.org/article/904b98ff799f4915b85da6385086ed22 |
| Accession Number: | edsdoj.904b98ff799f4915b85da6385086ed22 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16784219 00042803 |
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| DOI: | 10.1590/s0004-2803.201900000-62 |
| Published in: | Arquivos de Gastroenterologia |
| Language: | English |