Bibliographic Details
| Title: |
Transcriptional Signatures of Domestication Revealed through Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data |
| Authors: |
Motoki Uno, Hidemasa Bono |
| Source: |
Animals, Vol 14, Iss 13, p 1998 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Veterinary medicine
LCC:Zoology |
| Subject Terms: |
Sus scrofa domesticus, Sus scrofa, Gallus gallus, domesticated animals, breeding, gene set enrichment analysis, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| More Details: |
Domesticated animals have undergone significant changes in their behavior, morphology, and physiological functions during domestication. To identify the changes in gene expression associated with domestication, we collected the RNA-seq data of pigs, chickens, wild boars, and red junglefowl from public databases and performed a meta-analysis. Gene expression was quantified, and the expression ratio between domesticated animals and their wild ancestors (DW-ratio) was calculated. Genes were classified as “upregulated”, “downregulated”, or “unchanged” based on their DW-ratio, and the DW-score was calculated for each gene. Gene set enrichment analysis revealed that genes upregulated in pigs were related to defense from viral infection, whereas those upregulated in chickens were associated with aminoglycan and carbohydrate derivative catabolic processes. Genes commonly upregulated in pigs and chickens are involved in the immune response, olfactory learning, epigenetic regulation, cell division, and extracellular matrix. In contrast, genes upregulated in wild boar and red junglefowl are related to stress response, cell proliferation, cardiovascular function, neural regulation, and energy metabolism. These findings provide valuable insights into the genetic basis of the domestication process and highlight potential candidate genes for breeding applications. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-2615 |
| Relation: |
https://www.mdpi.com/2076-2615/14/13/1998; https://doaj.org/toc/2076-2615 |
| DOI: |
10.3390/ani14131998 |
| Access URL: |
https://doaj.org/article/904306b2d7954f15bf562d44897af993 |
| Accession Number: |
edsdoj.904306b2d7954f15bf562d44897af993 |
| Database: |
Directory of Open Access Journals |
