Bibliographic Details
| Title: |
Lipid Paradox in Statin-Naïve Acute Ischemic Stroke But Not Hemorrhagic Stroke |
| Authors: |
Kai-Hung Cheng, Jr-Rung Lin, Craig S. Anderson, Wen-Ter Lai, Tsong-Hai Lee, the SRICHS Group, Yeu-Jhy Chang, Chien-Hung Chang, Hsiu-Chuan Wu, Kuo-Lun Huang, Ting-Yu Chang, Chi-Hung Liu, Chih-Kuang Cheng, Te-Fa Chiu, Chi-Ren Huang, Ho-Fai Wong, Cheng-Hong Toh, Tsung-I Peng, Wen-Yi Huang, Yu-Yi Chien, Kong Chung, Hsiang-Yun Lo, Yao-Liang Chen, Jiann-Der Lee, Meng Lee, Yen-Chu Huang, Shao-Wen Chou, Cheng-Ting Hsiao, Yuan-Hsiung Tsai, Chia-Wei Liou, Ku-Chou Chang, Hung-Sheng Lin, Teng-Yeow Tan, Ru-Huei Fu, Wei Hsi Chen, Chia-Te Kung, Wei-Che Lin |
| Source: |
Frontiers in Neurology, Vol 9 (2018) |
| Publisher Information: |
Frontiers Media S.A., 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
ischemic stroke, intracerebral hemorrhage, lipids, mortality, stroke outcome, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Background: Low lipid level is associated with better cardiovascular outcome. However, lipid paradox indicating low lipid level having worse outcomes could be seen under acute injury in some diseases. The present study was designed to clarify the prognostic significance of acute-phase lipid levels within 1 day after admission for stroke on mortality in first-ever statin-naïve acute ischemic stroke (IS) and hemorrhagic stroke (HS).Methods: This observational study was conducted using the data collected from Stroke Registry In Chang-Gung Healthcare System (SRICHS) between 2009 and 2012. Patients with recurrent stroke, onset of symptoms >1 day, and history of the use of lipid-lowering agents prior to index stroke were excluded. Stroke was classified into IS and hypertension-related HS. The primary outcomes were 30-day and 1-year mortality identified by linkage to national death registry for date and cause of death. Receiver operating characteristic (ROC) curve analysis and multivariate Cox proportional hazard models were used to examine the association of lipid profiles on admission with mortality.Results: Among the 18,268 admitted stroke patients, 3,746 IS and 465 HS patients were eligible for analysis. In IS, total cholesterol (TC) |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fneur.2018.00541/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2018.00541 |
| Access URL: |
https://doaj.org/article/902c2c50c73844afa139a7095a404f17 |
| Accession Number: |
edsdoj.902c2c50c73844afa139a7095a404f17 |
| Database: |
Directory of Open Access Journals |
