Bibliographic Details
| Title: |
Arrhythmogenic right ventricular cardiomyopathy: diverse substrate characteristics and ablation outcome |
| Authors: |
Wen-Han Cheng, Fa-Po Chung, Yenn-Jiang Lin, Li-Wei Lo, Shih-Lin Chang, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Shih-Ann Chen |
| Source: |
Reviews in Cardiovascular Medicine, Vol 22, Iss 4, Pp 1295-1309 (2021) |
| Publisher Information: |
IMR Press, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
arrhythmogenic right ventricular cardiomyopathy, epicardial approach, substrates, ventricular fibrillation, ventricular tachycardia, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy caused by defective desmosomal proteins. The typical histopathological finding of ARVC is characterized by progressive fibrofatty infiltration of the right ventricle due to the dysfunction of cellular adhesion molecules, thus, developing arrhythmogenic substrates responsible for the clinical manifestation of ventricular tachycardia/fibrillation (VT/VF). Current guidelines recommend implantable cardiac defibrillator (ICD) implantation to prevent sudden cardiac death (SCD) in ARVC, especially for those experiencing VT/VF or aborted SCD, while antiarrhythmic drugs, despite their modest effectiveness and several undesirable adverse effects, are frequently used for those experiencing episodes of ICD interventions. Given the advances in mapping and ablation technologies, catheter ablation has been implemented to eliminate drug-refractory VT in ARVC. A better understanding of the pathogenesis, underlying arrhythmogenic substrates, and putative VT isthmus in ARVC contributes to a significant improvement in ablation outcomes through comprehensive endocardial and epicardial approaches. Regardless of ablation strategies, there is a diversity of arrhythmogenic substrates in ARVC, which could partly explain the nonuniform ablation outcome and long-term recurrences and reflect the role of potential factors in the modification of disease progression and triggering of arrhythmic events. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2153-8174 |
| Relation: |
https://rcm.imrpress.com/EN/10.31083/j.rcm2204136; https://doaj.org/toc/2153-8174 |
| DOI: |
10.31083/j.rcm2204136 |
| Access URL: |
https://doaj.org/article/902a6bdc658f4e6693b07fe0a1df75f3 |
| Accession Number: |
edsdoj.902a6bdc658f4e6693b07fe0a1df75f3 |
| Database: |
Directory of Open Access Journals |
