Bibliographic Details
| Title: |
A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: a preliminary study |
| Authors: |
Yuka Kajita, Tsuguaki Terashima, Hisatake Mori, Md. Monirul Islam, Takayuki Irahara, Masanobu Tsuda, Hideki Kano, Naoshi Takeyama |
| Source: |
Journal of Intensive Care, Vol 9, Iss 1, Pp 1-9 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: |
Glycocalyx, ARDS, Septic shock, Hyperpermeability, Syndecan-1, Cumulative fluid balance, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: |
Abstract Background The purpose of this study is to investigate the time course of syndecan-1 (Syn-1) plasma levels, the correlation between Syn-1 and organ damage development, and the associations of Syn-1 level with cumulative fluid balance and ventilator-free days (VFD) in patients with septic shock. Methods We collected blood samples from 38 patients with septic shock upon their admission to ICU and for the first 7 days of their stay. Syn-1 plasma level, acute respiratory distress syndrome (ARDS), other organ damage, VFD, and cumulative fluid balance were assessed daily. Results Over the course of 7 days, Syn-1 plasma levels increased significantly more in patients with ARDS than in those without ARDS. Patients with high levels of Syn-1 in the 72 h after ICU admission had significantly higher cumulative fluid balance, lower PaO2/FiO2, and fewer VFD than patients with low levels of Syn-1. Syn-1 levels did not correlate with sequential organ failure assessment score or with APACHE II score. Conclusions In our cohort of patients with septic shock, higher circulating level of Syn-1 of cardinal glycocalyx component is associated with more ARDS, cumulative positive fluid balance, and fewer VFD. Measurement of Syn-1 levels in patients with septic shock might be useful for predicting patients at high risk of ARDS. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2052-0492 |
| Relation: |
https://doaj.org/toc/2052-0492 |
| DOI: |
10.1186/s40560-021-00543-x |
| Access URL: |
https://doaj.org/article/c90130e2504642008721474336801261 |
| Accession Number: |
edsdoj.90130e2504642008721474336801261 |
| Database: |
Directory of Open Access Journals |
