A preponderance of gastrointestinal cancer patients transition into cachexia syndrome
| Title: | A preponderance of gastrointestinal cancer patients transition into cachexia syndrome |
|---|---|
| Authors: | Linda Anne Gilmore, Santiago Olaechea, Brian W. Gilmore, Bhavani S. Gannavarapu, Christian M. Alvarez, Chul Ahn, Puneeth Iyengar, Rodney E. Infante |
| Source: | Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 2920-2931 (2022) |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| Subject Terms: | colorectal cancer, gastroesophageal cancer, hepatobiliary cancer, pancreatic cancer, weight loss, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| More Details: | Abstract Background Cancer cachexia is frequently documented by self‐reported, single time‐point weight histories. This approach lacks the granularity needed to fully elucidate the progression of cachexia syndrome. This study aimed to longitudinally assess body weight changes pre‐ and post‐cancer diagnosis in gastrointestinal (GI) cancer patients. Methods Body weights and relevant clinical data recorded in the electronic health record 12 months pre‐ and post‐GI cancer (colorectal, gastroesophageal, hepatobiliary and pancreatic) diagnosis were extracted. Weight loss was categorized by the International Consensus Definition for cachexia. Results A total of 879 patients were included in the final cohort including patients diagnosed with colorectal (n = 317), hepatocellular (n = 185), biliary (n = 72), pancreatic (n = 186) or gastroesophageal (n = 119) cancer. Stage of disease was equally distributed. Patients without cachexia at diagnosis (n = 608) remained weight stable during the 12 months pre‐diagnosis (+0.5 ± 0.5% body weight; P = 0.99). Patients with cachexia at diagnosis (n = 271) remained weight stable 6 to 12 months prior to diagnosis (+0.4 ± 0.8%; P > 0.9999) and lost 8.7 ± 0.6% (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.13086 |
| Access URL: | https://doaj.org/article/8fe65dbca99243858afc6ef020d6cf80 |
| Accession Number: | edsdoj.8fe65dbca99243858afc6ef020d6cf80 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.13086 |
| Published in: | Journal of Cachexia, Sarcopenia and Muscle |
| Language: | English |