| Title: |
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma |
| Authors: |
Yongfei Yang, Meiying Luo, Kexin Zhang, Jun Zhang, Tongtong Gao, Douglas O’ Connell, Fengping Yao, Changwen Mu, Bingyu Cai, Yuxue Shang, Wei Chen |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Erastin, the ferroptosis activator, binds to voltage gated ion channels CDAC2 and VDCA3 but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitination and subsequent degradation of the channels. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-14324-x |
| Access URL: |
https://doaj.org/article/8f3cb0fc75d84affa78fca2ae1a5777c |
| Accession Number: |
edsdoj.8f3cb0fc75d84affa78fca2ae1a5777c |
| Database: |
Directory of Open Access Journals |
