Bibliographic Details
| Title: |
KRAS insertion mutations are oncogenic and exhibit distinct functional properties |
| Authors: |
Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva, Gideon Bollag, Chao Zhang, Heidi Carias, David Dickens, Mignon Loh, Kevin Shannon, Ari J. Firestone |
| Source: |
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016) |
| Publisher Information: |
Nature Portfolio, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Amino acid substitutions in K-Ras that constitutively activate the protein are common in cancer. Here, the authors describe mutations in the K-RasSwitch 2 domain and show that the mutant proteins accumulate in the active conformation, exhibit defective binding to PI3 kinase, and are hypersensitive to MEK inhibitors. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/ncomms10647 |
| Access URL: |
https://doaj.org/article/c8ee34111da64f238c6f182195674d48 |
| Accession Number: |
edsdoj.8ee34111da64f238c6f182195674d48 |
| Database: |
Directory of Open Access Journals |
