Images in Immunotherapy and Precision Oncology: Angiosarcoma of the Spleen and Liver
| Title: | Images in Immunotherapy and Precision Oncology: Angiosarcoma of the Spleen and Liver |
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| Authors: | Anagha Deshpande, Javier Munoz, Katalin Kelemen, Vrushali Dabak, Amr Hanbali, Razelle Kurzrock |
| Source: | Journal of Immunotherapy and Precision Oncology, Pp 56-58 (2023) |
| Publisher Information: | Innovative Healthcare Institute, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Immunologic diseases. Allergy |
| Subject Terms: | splenic angiosarcoma, hepatic angiosarcoma, nivolumab, ipilimumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Immunologic diseases. Allergy, RC581-607 |
| More Details: | Primary splenic or hepatic angiosarcomas are ultra-rare and aggressive malignancies associated with poor prognosis. The mainstay treatments are surgical resection and chemotherapy. We report a case of angiosarcoma in a 50-year-old woman who presented with bruising, fatigue, ecchymosis, and hepatosplenomegaly. She was treated with the multi-kinase inhibitor sunitinib for 4 weeks before developing a splenic hemorrhage and succumbing. Recent studies have demonstrated the clinical benefit of immunotherapies in angiosarcomas. Additionally, sequencing techniques have showcased the diverse molecular aberrations involved in angiosarcomas, which offer opportunities for precision-matched targeted therapies such as inhibitors of the VEGF/VEGFR axis and PI3K/Akt/mTor pathway. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2666-2345 2590-017X |
| Relation: | https://doaj.org/toc/2666-2345; https://doaj.org/toc/2590-017X |
| DOI: | 10.36401/JIPO-22-22 |
| Access URL: | https://doaj.org/article/8e06bad67679485d8fdfb563e1d7cf3c |
| Accession Number: | edsdoj.8e06bad67679485d8fdfb563e1d7cf3c |
| Database: | Directory of Open Access Journals |
| ISSN: | 26662345 2590017X |
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| DOI: | 10.36401/JIPO-22-22 |
| Published in: | Journal of Immunotherapy and Precision Oncology |
| Language: | English |