Academic Journal
Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran
| Title: | Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran |
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| Authors: | Mir Reza Ghaemi, Sara Hemmati, Arezou Rezaei, Maryam Sadr, Bahareh Mohebbi, Hosseinali Ghaffaripour, Nima Rezaei, Seyed Alireza Mahdaviani |
| Source: | Acta Medica Iranica, Vol 57, Iss 11 (2020) |
| Publisher Information: | Tehran University of Medical Sciences, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Medicine (General) |
| Subject Terms: | Asthma, ADAM33, rs2280091, Polymorphisms, Medicine (General), R5-920 |
| More Details: | There is strong evidence on the interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 rs2280091 polymorphism and pediatric asthma in the Iranian population. A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification, and severity were defined. SNPs of the ADAM33 gene at rs2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count, and IgE count were also assessed. T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 rs2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0044-6025 1735-9694 |
| Relation: | https://acta.tums.ac.ir/index.php/acta/article/view/8163; https://doaj.org/toc/0044-6025; https://doaj.org/toc/1735-9694 |
| DOI: | 10.18502/acta.v57i11.3259 |
| Access URL: | https://doaj.org/article/8dc08c6965dd45a3a95eb9519b0bcdb1 |
| Accession Number: | edsdoj.8dc08c6965dd45a3a95eb9519b0bcdb1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 00446025 17359694 |
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| DOI: | 10.18502/acta.v57i11.3259 |
| Published in: | Acta Medica Iranica |
| Language: | English |