Academic Journal
The causal effect of educational attainment on stress urinary incontinence: a two-sample mendelian randomization study
| Title: | The causal effect of educational attainment on stress urinary incontinence: a two-sample mendelian randomization study |
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| Authors: | Shufei Zhang, Mao Chen, Jianfeng Liu, Lian Yang, Hanyue Li, Li Hong |
| Source: | BMC Women's Health, Vol 23, Iss 1, Pp 1-7 (2023) |
| Publisher Information: | BMC, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Gynecology and obstetrics LCC:Public aspects of medicine |
| Subject Terms: | Stress urinary incontinence, Mendelian randomization, Educational attainment, Years of schooling, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270 |
| More Details: | Abstract Background Stress urinary incontinence (SUI) is characterized by involuntary urine leakage in response to increased abdominal pressure, such as coughing, laughing, or sneezing. It significantly affects women’s quality of life and imposes a substantial disease burden. While pregnancy and childbirth have been previously identified as risk factors for SUI, educational attainment may also play a role. Therefore, this paper investigates the causal relationship between educational attainment and SUI using two-sample Mendelian randomization (TSMR) analysis, years of schooling (YOS), and college or university degree (CUD) as proxies. Methods Summary statistics of YOS, CUD, and SUI were obtained from genome-wide association studies (GWAS), and TSMR analysis was applied to explore potential causal relationships between them. Causal effects were mainly estimated using the standard inverse variance weighting (IVW) method, and complementary and sensitivity analyses were also performed using multiple methods. Results The results indicate that both YOS (OR = 0.994, 95% CI: 0.992–0.996; P = 7.764E-10) and CUD (OR = 0.987, 95% CI: 0.983–0.991; P = 1.217E-09) may have a negative causal effect on SUI. Conclusions Improving educational attainment may go some way towards reducing the risk of SUI. Therefore, it is important to increase efforts to improve the imbalance in educational development and safeguard women’s health. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1472-6874 |
| Relation: | https://doaj.org/toc/1472-6874 |
| DOI: | 10.1186/s12905-023-02724-2 |
| Access URL: | https://doaj.org/article/8d849cc42275402192394c339cfe866e |
| Accession Number: | edsdoj.8d849cc42275402192394c339cfe866e |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14726874 |
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| DOI: | 10.1186/s12905-023-02724-2 |
| Published in: | BMC Women's Health |
| Language: | English |