| Title: |
Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet |
| Authors: |
Song Liu, Shaochun Yuan, Xiaoman Gao, Xin Tao, Wenjuan Yu, Xu Li, Shangwu Chen, Anlong Xu |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon activity and maintaining genome stability. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-18261-7 |
| Access URL: |
https://doaj.org/article/8cf8cad9388848f799e5b8818620cbce |
| Accession Number: |
edsdoj.8cf8cad9388848f799e5b8818620cbce |
| Database: |
Directory of Open Access Journals |
