Bibliographic Details
| Title: |
Childhood Adversity and White Matter Microstructure: White Matter Differences Associated with Trauma Exposure |
| Authors: |
Andrea Rodriguez, Helen Petropoulos, Pilar M. Sanjuan, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Julia M. Stephen |
| Source: |
Stresses, Vol 5, Iss 1, p 19 (2025) |
| Publisher Information: |
MDPI AG, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
diffusion tensor imaging (DTI), posttraumatic stress, childhood trauma, typically developing youth, Biology (General), QH301-705.5 |
| More Details: |
Current research on the effects of childhood trauma largely focuses on maltreatment. In the current study, we used diffusion tensor imaging (DTI) to determine the association between potentially traumatic exposures not related to maltreatment and fractional anisotropy (FA) in 184 youth aged 9–14 years. The Trauma History Profile was used to determine how many traumatic events in different categories were experienced and create low- and high-trauma groups. FA values were compared between groups in twelve a priori chosen regions of interest (ROIs). Five of the twelve regions showed significantly lower FA in the high-trauma groups when compared to the low-trauma groups, including the body of the corpus callosum, the total corpus callosum, bilateral posterior thalamic radiation, and the left cingulate gyrus projection of the cingulum bundle. Group differences were also observed across a range of behaviors. However, FA was not associated with posttraumatic stress symptomology. The results support the hypothesis that the high-trauma group had lower FA compared to the low-trauma group. The significant ROIs represent a subset of regions identified in studies of adults exposed to traumatic childhood events or children with a history of maltreatment. These results, obtained from typically developing youth, underline the importance of examining childhood trauma exposure in future developmental studies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-7140 |
| Relation: |
https://www.mdpi.com/2673-7140/5/1/19; https://doaj.org/toc/2673-7140 |
| DOI: |
10.3390/stresses5010019 |
| Access URL: |
https://doaj.org/article/c8cdcf0bca7d4168b08e46df89f7a328 |
| Accession Number: |
edsdoj.8cdcf0bca7d4168b08e46df89f7a328 |
| Database: |
Directory of Open Access Journals |
