Bibliographic Details
| Title: |
Opioids and Chronic Pain: An Analytic Review of the Clinical Evidence |
| Authors: |
Stephen E. Nadeau, Jeffrey K. Wu, Richard A. Lawhern |
| Source: |
Frontiers in Pain Research, Vol 2 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
opioids, opioid efficacy, opioid dosage, opioid mortality, opioid use disorder, opioid crisis, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
We conducted an analytic review of the clinical scientific literature bearing on the use of opioids for treatment of chronic non-cancer pain in the United States. There is substantial, albeit not definitive, scientific evidence of the effectiveness of opioids in treating pain and of high variability in opioid dose requirements and side effects. The estimated risk of death from opioid treatment involving doses above 100 MMED is ~0.25%/year. Multiple large studies refute the concept that short-term use of opioids to treat acute pain predisposes to development of opioid use disorder. The prevalence of opioid use disorder associated with prescription opioids is likely |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-561X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fpain.2021.721357/full; https://doaj.org/toc/2673-561X |
| DOI: |
10.3389/fpain.2021.721357 |
| Access URL: |
https://doaj.org/article/8c854223ad79416590d004e9e33435f6 |
| Accession Number: |
edsdoj.8c854223ad79416590d004e9e33435f6 |
| Database: |
Directory of Open Access Journals |
