An Evaluation of Cytotoxicity of Iron Oxide Nanoparticles with Hydrogen Peroxide Endodontic Irrigant
| Title: | An Evaluation of Cytotoxicity of Iron Oxide Nanoparticles with Hydrogen Peroxide Endodontic Irrigant |
|---|---|
| Authors: | Saraa N. Al-Malla, Ali M. Al-Naimi |
| Source: | Al-Rafidain Dental Journal, Vol 23, Iss 1, Pp 1-8 (2023) |
| Publisher Information: | University of Mosul, College of Dentistry, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Dentistry |
| Subject Terms: | cytotoxicit human dermal fibroblast cells hydrogen peroxide iron oxide irrigating solutions, Dentistry, RK1-715 |
| More Details: | Aims: The aim of this research was to determine the cytotoxic effect of different concentrations of iron oxide nanoparticles (IONPs) in combination with hydrogen peroxide (H2O2) in vitro as a potential endodontic irrigating solution. Materials and Methods: Cytotoxicity of IONPs at concentrations (8, 4, 2, 1, 0.5, and 0.25 mg/ml) with 3% H2O2 were evaluated on cultured Human Dermal Fibroblast (HDFn) cell lines. Cytotoxicity was assessed after 10 minutes of exposure using Mossman’s Tetrazolium Toxicity (MTT) assay. Results: Tukey’s test indicated that no significant difference in cell viability was found at lower concentrations (0.2, 0.5, 1, and 2 mg/ml). While at a concentration of 4 and 8 mg/ml, the cell viability was not significantly different from each other whereas, significantly different from previous concentrations. Conclusion: From the gained data, it can be deduced that IONPs+H2O2 had almost no cytotoxic effect on HDFn cell viability at concentrations 0.2, 0.5, 1, and 2 mg/ml, while a moderate decrease of survival has been observed at concentrations 4 and 8 mg/ml. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Arabic English |
| ISSN: | 1812-1217 1998-0345 |
| Relation: | https://rden.mosuljournals.com/article_173018_111d9f7c55bfe25dac910c76e2fbd2ae.pdf; https://doaj.org/toc/1812-1217; https://doaj.org/toc/1998-0345 |
| DOI: | 10.33899/rden.2021.129103.1069 |
| Access URL: | https://doaj.org/article/8c5795ddf20b4d32975bc3ab85a9047a |
| Accession Number: | edsdoj.8c5795ddf20b4d32975bc3ab85a9047a |
| Database: | Directory of Open Access Journals |
| ISSN: | 18121217 19980345 |
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| DOI: | 10.33899/rden.2021.129103.1069 |
| Published in: | Al-Rafidain Dental Journal |
| Language: | Arabic English |