Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework
| Title: | Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework |
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| Authors: | Jeremy M. C. Brown, Gerard G. Hanna, Nathanael Lampe, Balder Villagomez-Bernabe, James R. Nicol, Jonathan A. Coulter, Fred J. Currell |
| Source: | Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-13 (2018) |
| Publisher Information: | BMC, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Radiotherapy, Nanoparticles, Treatment planning, Radiosensitisers, Biological effect modelling, Theranostic nanoparticles, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and high Z NP-doped adult female phantom. Application of the RBED framework found that the extent of possible biological response with high Z NP doping was great than expected via the dose deposition alone. It is anticipated that this framework will assist the scientific community in future high Z NP-enhanced in-silico, pre-clinical and clinical trials. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1868-6958 1868-6966 |
| Relation: | http://link.springer.com/article/10.1186/s12645-018-0043-7; https://doaj.org/toc/1868-6958; https://doaj.org/toc/1868-6966 |
| DOI: | 10.1186/s12645-018-0043-7 |
| Access URL: | https://doaj.org/article/dc8bcf0877f34e35a7fc746e9975d94b |
| Accession Number: | edsdoj.8bcf0877f34e35a7fc746e9975d94b |
| Database: | Directory of Open Access Journals |
| ISSN: | 18686958 18686966 |
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| DOI: | 10.1186/s12645-018-0043-7 |
| Published in: | Cancer Nanotechnology |
| Language: | English |