Antiplatelet Therapy and Bleeding Outcomes With CYP2C19 Genotyping
| Title: | Antiplatelet Therapy and Bleeding Outcomes With CYP2C19 Genotyping |
|---|---|
| Authors: | James C. Coons PharmD, James M. Stevenson PharmD, MS, Ami Patel PharmD, A. J. Conrad Smith MD, Linda Prebehalla BSN, RN, Philip E. Empey PharmD, PhD |
| Source: | Journal of Cardiovascular Pharmacology and Therapeutics, Vol 27 (2022) |
| Publisher Information: | SAGE Publishing, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Therapeutics. Pharmacology |
| Subject Terms: | Diseases of the circulatory (Cardiovascular) system, RC666-701, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Purpose: The impact of antiplatelet therapy with availability of CYP2C19 genotyping on bleeding in a real-world setting has not been extensively studied. Methods: Prospective, single-center, cohort study conducted between December 2015 and October 2019 with 1-year follow-up. Patients underwent percutaneous coronary intervention (PCI), CYP2C19 genotyping, and received P2Y12 inhibitor therapy. The primary outcome was time to first bleed of any severity using Bleeding Academic Research Consortium criteria. Secondary outcomes included time to first major bleed and rates of antiplatelet switching. Results: The primary outcome occurred in 697 of 2091 (33%) participants at a median of 15 days. Major bleeding occurred in 176 (8%) of patients. Compared to clopidogrel, treatment with ticagrelor or prasugrel was associated with increased risk of any bleeding (adjusted HR [aHR] 2.04, 95% CI 1.69-2.46). For patients without CYP2C19 no function alleles, treatment with prasugrel or ticagrelor was associated with increased risk of any bleeding (aHR 2.31, 95% CI 1.83-2.90). Similar associations were observed for major bleeding. No difference in ischemic events was observed. Among patients discharged on ticagrelor or prasugrel, 199 (36%) were de-escalated to clopidogrel within 1 year. De-escalation was more likely after a bleed if patients did not have a no function allele (35.9% vs 19.1%; P = .02). Conclusion: Bleeding is common in post-PCI patients on antiplatelet therapy. Patients on high potency agents had higher bleeding risk in the population at-large and in non-carriers of CYP2C19 no function alleles. Genotype-guided antiplatelet de-escalation should be further explored in prospective studies. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1940-4034 10742484 |
| Relation: | https://doaj.org/toc/1940-4034 |
| DOI: | 10.1177/10742484221143246 |
| Access URL: | https://doaj.org/article/8bab12ba233a49468eb51969dc2280f1 |
| Accession Number: | edsdoj.8bab12ba233a49468eb51969dc2280f1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 19404034 10742484 |
|---|---|
| DOI: | 10.1177/10742484221143246 |
| Published in: | Journal of Cardiovascular Pharmacology and Therapeutics |
| Language: | English |