Academic Journal
The miR-641-STIM1 and SATB1 axes play important roles in the regulation of the Th17/Treg balance in ITP
| Title: | The miR-641-STIM1 and SATB1 axes play important roles in the regulation of the Th17/Treg balance in ITP |
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| Authors: | Hongkai Zhu, Xueqin Ruan, Kexin Zhao, Wenyong Kuang, Sufang Liu, Wenzhe Yan, Xianming Fu, Zhao Cheng, Ruijuan Li, Hongling Peng |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Immune thrombocytopenia (ITP), Th17/Treg balance, microRNA 641 (miR-641), SATB1, STIM1, Medicine, Science |
| More Details: | Abstract Immune thrombocytopenia (ITP) is an autoimmune disease caused by T-cell dysfunction. Recently, several studies have shown that a disturbed Th17/Treg balance contributes to the development of ITP. MicroRNAs (miRNAs) are small noncoding RNA moleculesthat posttranscriptionally regulate gene expression. Emerging evidences have demonstrated that miRNAs play an important role in regulating the Th17/Treg balance. In the present study, we found that miR-641 was upregulated in ITP patients. In primary T cells, overexpression of miR-641 could cause downregulation of its target genes STIM1 and SATB1, thus inducing a Th17 (upregulated)/Treg (downregulated) imbalance. Inhibition of miR-641 by a miR-641 sponge in primary T cells of ITP patients or by antagomiR-641 in an ITP murine model could cause upregulation of STIM1 and SATB1, thus restoring Th17/Treg homeostasis. These results suggested that the miR-641-STIM/SATB1 axis plays an important role in regulating the Th17/Treg balance in ITP. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-61660-9 |
| Access URL: | https://doaj.org/article/8b93757099d041abaf1df398b05d307b |
| Accession Number: | edsdoj.8b93757099d041abaf1df398b05d307b |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-61660-9 |
| Published in: | Scientific Reports |
| Language: | English |