Bibliographic Details
| Title: |
Unsupervised subtyping of motor dysfunction of Parkinson's disease and its structural brain imaging correlates |
| Authors: |
Yu-Fan Lin, Jong-Ling Fuh, Albert C. Yang |
| Source: |
NeuroImage: Reports, Vol 5, Iss 1, Pp 100246- (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Parkinson's disease, Motor dysfunction subtypes, Structural brain imaging, Machine learning, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Background: Parkinson's disease (PD) is a clinical neurodegenerative disorder. The Unified Parkinson's Disease Rating Scale (UPDRS) has been used as a standard measure of the PD symptom profile, and magnetic resonance (MR) imaging is widely used for identifying the critical brain regions involved in PD progression. Objectives: The present study aimed to (1) identify PD subtypes based on the motor dysfunction profile in the MDS-UPDRS and (2) find the differences in gray matter volumes of brain regions, and (3) compare non-motor features between the subtypes to explore their distinct clinical profiles. Methods: In total, 299 patients with PD and 173 healthy participants from the Parkinson's Progression Markers Initiative were included. A software package, Generalized Association Plots, was used to cluster the motor dysfunction profile in the MDS-UPDRS. Regression models and the Artificial Intelligence Platform as a Service were used to quantify the differences in gray matter volume of brain regions between subtypes. Results: We identified three PD subtypes—resting tremor, intermediate, and akinetic-rigid—using motor symptom clustering. MRI analysis revealed significant differences in brain regions, including the posterior cingulate gyrus, lenticular nucleus, olfactory cortex, and cerebellum. Non-motor features, such as cognitive decline and autonomic dysfunctions, varied across subtypes, highlighting distinct systemic profiles. Akinetic-rigid patients exhibited the most severe impairments, while tremor-dominant patients showed milder non-motor symptoms. Discussion: Three PD subtypes of motor dysfunction were identified. Structural brain imaging revealed subtype-specific differences not only in cingulum and putamen regions, but also in the olfactory cortex, parahippocampal gyrus, and cerebellum, correlating with motor symptoms. Non-motor features varied by subtype, with increasing severity from tremor-dominant to akinetic-rigid. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2666-9560 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666956025000145; https://doaj.org/toc/2666-9560 |
| DOI: |
10.1016/j.ynirp.2025.100246 |
| Access URL: |
https://doaj.org/article/c8b661f8cb504cf99cf98ef196211002 |
| Accession Number: |
edsdoj.8b661f8cb504cf99cf98ef196211002 |
| Database: |
Directory of Open Access Journals |
