Bibliographic Details
| Title: |
Add-On Therapy with DPP-4 Inhibitors May Improve Renal Function Decline in α-Glucosidase Inhibitor and Metformin Users: A Retrospective Observational Study |
| Authors: |
Osonoi T, Saito M, Koda N, Douguchi S, Nakano T, Ofuchi K, Katoh M |
| Source: |
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 13, Pp 3497-3506 (2020) |
| Publisher Information: |
Dove Medical Press, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Specialties of internal medicine |
| Subject Terms: |
dpp-4 inhibitor, α-glucosidase inhibitor, metformin, egfr slope, type 2 diabetes, Specialties of internal medicine, RC581-951 |
| More Details: |
Takeshi Osonoi, Miyoko Saito, Naoya Koda, Satako Douguchi, Takako Nakano, Kensuke Ofuchi, Makoto Katoh Naka Kinen Clinic, Ibaraki, JapanCorrespondence: Makoto KatohNaka Kinen Clinic, 745-5 Nakadai, Naka-Shi, Ibaraki 311-0113, JapanTel +81-29-353-2800Fax +81-29-295-5400Email m-katou@kensei-kai.comPurpose: We retrospectively evaluated the long-term effect of dipeptidyl peptidase (DPP)-4 inhibitors on estimated glomerular filtration rate (eGFR) slopes, and then evaluated the beneficial interaction between DPP-4 inhibitor initiation and baseline use of α-glucosidase inhibitor and/or metformin in patients with diabetic kidney disease.Patients and Methods: Altogether, 1512 patients with type 2 diabetes were receiving DPP-4 inhibitor therapy over 1 year and were followed up for a maximum of 2 years before and after 7 years of treatment. The decline in renal function was estimated as the slope of the individual linear regression line of eGFR over 2-year follow-up. Prescription data on medications before and after DPP-4 inhibitor treatment were examined.Results: The mean length of DPP-4 inhibitor treatment was 5.3 ± 2.6 years. The baseline mean eGFR slope (mL/min/1.73m2/year) was − 2.24 ± 6.05. After DPP-4 inhibitor treatment, mean eGFR slope was significantly improved (− 1.53 ± 6.36, P < 0.01) in patients with type 2 diabetes. This effect appeared more pronounced for baseline use of α-glucosidase inhibitor and/or metformin in patients with diabetic kidney disease. These non-users showed a trend towards attenuation or no effects.Conclusion: In the present study, patients treated with DPP-4 inhibitors had a significantly slower annual loss of kidney function. The benefit appears pronounced in α-glucosidase inhibitor and metformin users with advanced renal dysfunction. These results suggest that the beneficial effects of DPP-4 inhibitors on kidney function may have occurred in the presence of an α-glucosidase inhibitor and/or metformin.Keywords: DPP-4 inhibitor, α-glucosidase inhibitor, metformin, eGFR slope, type 2 diabetes |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1178-7007 |
| Relation: |
https://www.dovepress.com/add-on-therapy-with-dpp-4-inhibitors-may-improve-renal-function-declin-peer-reviewed-article-DMSO; https://doaj.org/toc/1178-7007 |
| Access URL: |
https://doaj.org/article/8b5d79d40e3f4f0ba712bb5cf5f548e4 |
| Accession Number: |
edsdoj.8b5d79d40e3f4f0ba712bb5cf5f548e4 |
| Database: |
Directory of Open Access Journals |
