Bibliographic Details
| Title: |
Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? |
| Authors: |
Lisa Bauer, Debby van Riel |
| Source: |
mBio, Vol 14, Iss 1 (2023) |
| Publisher Information: |
American Society for Microbiology, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
neuropathogenesis, neuroinvasion, neurotropism, neurovirulence, CNS, astrocytes, Microbiology, QR1-502 |
| More Details: |
ABSTRACT Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the central nervous system. Kong et al. (https://doi.org/10.1128/mbio.02308-22) shows that the mechanism of virus entry into astrocytes in brain organoids and primary astrocytes differs from entry into respiratory epithelial cells. However, how SARS-CoV-2 enters susceptible CNS cells and whether there are differences among SARS-CoV-2 variants is still unclear. In vivo and in vitro models are useful to study these important questions and may reveal important differences among SARS-CoV-2 variants in their neuroinvasive, neurotropic, and neurovirulent potential. In this commentary we address how this study contributes to the understanding of the neuropathology of SARS-CoV-2 and its variants. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2150-7511 |
| Relation: |
https://doaj.org/toc/2150-7511 |
| DOI: |
10.1128/mbio.02920-22 |
| Access URL: |
https://doaj.org/article/8ae2e3e3feb1415ba71b4df088e3873d |
| Accession Number: |
edsdoj.8ae2e3e3feb1415ba71b4df088e3873d |
| Database: |
Directory of Open Access Journals |
