Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve

Bibliographic Details
Title: Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve
Authors: A. Arcucci, M.R. Ruocco, F. Albano, G. Granato, V. Romano, G. Corso, C. Bancone, E. De Vendittis, A. Della Corte, S. Montagnani
Source: European Journal of Histochemistry, Vol 58, Iss 3 (2014)
Publisher Information: PAGEPress Publications, 2014.
Publication Year: 2014
Collection: LCC:Biology (General)
Subject Terms: Ascending aortic aneurysm, bicuspid aortic valve, medial degeneration, smooth muscle cells, extracellular superoxide dismutase, Akt, tricuspid aortic valve., Biology (General), QH301-705.5
More Details: Ascending aortic aneurysm (AsAA) is a consequence of medial degeneration (MD), deriving from apoptotic loss of smooth muscle cells (SMC) and fragmentation of elastin and collagen fibers. Alterations of extracellular matrix structure and protein composition, typical of medial degeneration, can modulate intracellular pathways. In this study we examined the relevance of superoxide dismutase (SOD3) and Akt in AsAA pathogenesis, evaluating their tissue distribution and protein levels in ascending aortic tissues from controls (n=6), patients affected by AsAA associated to tricuspid aortic valve (TAV, n=9) or bicuspid aortic valve (BAV, n=9). The results showed a significant reduction of SOD3, phospho-Akt and Akt protein levels in AsAA tissues from patients with BAV, compared to controls, whereas the differences observed between controls and patients with TAV were not significant. The decreased levels of SOD3 and Akt in BAV aortic tissues are associated with decreased Erk1/Erk2 phosphorylation and MMP-9 levels increase. The authors suggest a role of decreased SOD3 protein levels in the progression of AsAA with BAV and a link between ECM modifications of aortic media layer and impaired Erk1/Erk2 and Akt signaling in the late stages of the aortopathy associated with BAV.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1121-760X
2038-8306
Relation: http://www.ejh.it/index.php/ejh/article/view/2383; https://doaj.org/toc/1121-760X; https://doaj.org/toc/2038-8306
DOI: 10.4081/ejh.2014.2383
Access URL: https://doaj.org/article/8adba09aafcb494e8d9ca762398134b3
Accession Number: edsdoj.8adba09aafcb494e8d9ca762398134b3
Database: Directory of Open Access Journals
More Details
ISSN:1121760X
20388306
DOI:10.4081/ejh.2014.2383
Published in:European Journal of Histochemistry
Language:English