Bibliographic Details
| Title: |
SARS-CoV-2 Omicron XBB.1 variant outbreak in a defined cohort: an epidemiological investigation incorporating longitudinal assessment of humoral response |
| Authors: |
Ili Margalit, Yael Weiss-Ottolenghi, Einat Panet, Victoria Indenbaum, Neta S. Zuckerman, Gili Joseph, Yovel Peretz, Noam Barda, Yaniv Lustig, Gili Regev-Yochay |
| Source: |
International Journal of Infectious Diseases, Vol 148, Iss , Pp 107240- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
COVID-19, Healthcare workers, Infection control, Virus neutralization, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Background: We describe an epidemiological investigation of a SARS-CoV-2-XBB.1 outbreak among healthcare workers (HCWs) returning from a 5-days educational tour abroad. Methods: We prospectively followed participants for symptoms and sampled blood for neutralization assays of four SARS-CoV-2 variants (wild type, XBB, EG.5.1, and BA.2.86) at 1, 3, and 6 months after their return. When available, samples from the 3 months preceding the outbreak were also tested. We compared geometric mean titers (GMT) of neutralizing antibodies of infected versus uninfected HCWs and febrile versus afebrile infected HCWs. Results: Nineteen (10%) of 181 HCWs were infected, all had mild COVID-19, 90% (17/19) had symptoms, and 16% (3/19) reported fever. Infected individuals tended to have lower pre-exposure XBB-neutralizing antibody titers (GMT of 32 versus 107 ID50, P = 0.248). Neutralization against XBB and newer subvariants peaked at 3 months and was higher among infected individuals (GMT 702 versus 156 [P < 0.001], 558 versus 163 [P = 0.001], and 558 vs. 182 [P = 0.002], ID50 for XBB, EG.5.1., and BA.2.86, respectively). By six months, these differences were no longer observed. Fever was positively associated with XBB neutralization (GMT 3474 versus 485, ID50 P = 0.005). Conclusions: Recently infected individuals are protected from reinfection with newer subvariants. However, protection is likely short lived. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971224003114; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2024.107240 |
| Access URL: |
https://doaj.org/article/8aba4d728ff3443ea79e9b1e1e053bb5 |
| Accession Number: |
edsdoj.8aba4d728ff3443ea79e9b1e1e053bb5 |
| Database: |
Directory of Open Access Journals |
