Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia
| Title: | Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia |
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| Authors: | C.-M. Baxter, H. J. Clothier, K. P. Perrett |
| Source: | Human Vaccines & Immunotherapeutics, Vol 14, Iss 8, Pp 2088-2092 (2018) |
| Publisher Information: | Taylor & Francis Group, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Therapeutics. Pharmacology |
| Subject Terms: | vaccine hypersensitivity, vaccine allergy, adverse events following immunization (aefi), Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Immediate hypersensitivity reactions (IHR) are rare but potentially serious adverse events following immunization (AEFI). Surveillance of Adverse Events following Vaccination in the Community (SAEFVIC) is an enhanced passive surveillance system that collects, analyses and reports information about AEFI in Victoria, Australia. We describe the incidence, timing and type of potential IHR following vaccination in preschool children reported over an 8-year period. A total of 2110 AEFI were reported in 1620 children, of which 23.5% (496) were classified as potential IHR. Of these, 37.1% (184) were suspected to be IgE-mediated, (including anaphylaxis, angioedema and/or urticaria) and 83.5% (414) occurred within 15 minutes of vaccination. The incidence of potential IHR was 5.4 per 100,000 doses, with that of suspected IgE-mediated IHR being 2.0 per 100,000 doses. The incidence of anaphylaxis was extremely low (0.13 per 100,000 doses) and is consistent with other published studies. Potential IHR following immunization should be reported to appropriate local pharmacovigilance systems and patients reviewed by specialists able to evaluate, investigate and manage future vaccinations. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2164-5515 2164-554X 21645515 |
| Relation: | https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X |
| DOI: | 10.1080/21645515.2018.1460293 |
| Access URL: | https://doaj.org/article/8ab9e64cc26244318e54f3ae481419a0 |
| Accession Number: | edsdoj.8ab9e64cc26244318e54f3ae481419a0 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21645515 2164554X |
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| DOI: | 10.1080/21645515.2018.1460293 |
| Published in: | Human Vaccines & Immunotherapeutics |
| Language: | English |