Real-world effectiveness of cytology and HPV-based screening strategy in cervical cancer screening: A cross-sectional population-based study in Chengdu, China.

Bibliographic Details
Title:	Real-world effectiveness of cytology and HPV-based screening strategy in cervical cancer screening: A cross-sectional population-based study in Chengdu, China.
Authors:	Boshuang Yao, Jieru Peng, Wei Song, Liu Yang, Meng Zhang, Xia Wu, Shiyi Wu, Xiaoyu Wang, Chunrong Li, Chunxia Yang
Source:	PLoS ONE, Vol 19, Iss 2, p e0299651 (2024)
Publisher Information:	Public Library of Science (PLoS), 2024.
Publication Year:	2024
Collection:	LCC:Medicine LCC:Science
Subject Terms:	Medicine, Science
More Details:	Cervical cancer poses a significant health challenge in developing countries, emphasizing the need for appropriate screening strategies to accelerate the elimination of this disease. This study summarized the results of a large-scale community-based cervical cancer screening program conducted in Chengdu, China, to understand the prevalence of HPV infection and cervical lesions in the population, and to compare the real-world effectiveness of two different screening methods implemented in the program. From January 2021 to December 2022, a total of 363,376 women aged 35-64 years in Chengdu received free screenings. Among these participants, 70.1% received cytology screening and 29.9% received HPV testing combined with 16/18 genotyping and cytology triage. Ultimately, 824 cases of high-grade lesions and cervical cancer were detected, with a total detection rate of cervical cancer and precancerous lesions of 226.8 per 100,000. The follow-up rate of patients with high-grade lesions and above was 98.9%, and the treatment rate was 86.6%. The overall high-risk HPV infection rate was 11.7%, with the HPV 16/18 infection rate of 1.4%. The rate of abnormal cytology results was 2.8%. The attendance rates for colposcopy and histopathology were 71.6% and 86.1%, respectively. By calculating the age-standardized rates to eliminate the different age composition between the two group, the HPV-based screening strategy had a higher rate of primary screening abnormalities (3.4% vs. 2.8%, P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1932-6203
Relation:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299651&type=printable; https://doaj.org/toc/1932-6203
DOI:	10.1371/journal.pone.0299651&type=printable
DOI:	10.1371/journal.pone.0299651
Access URL:	https://doaj.org/article/d8a9fa0c214e4965a9e5585fc3296342
Accession Number:	edsdoj.8a9fa0c214e4965a9e5585fc3296342
Database:	Directory of Open Access Journals
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More Details
ISSN:	19326203
DOI:	10.1371/journal.pone.0299651&type=printable
Published in:	PLoS ONE
Language:	English