Bibliographic Details
| Title: |
Natural history observations in moderate aortic stenosis |
| Authors: |
Yu Du, Mario Gössl, Santiago Garcia, Maurice Enriquez-Sarano, Joao L. Cavalcante, Richard Bae, Go Hashimoto, Miho Fukui, Bernardo Lopes, Aisha Ahmed, Christian Schmidt, Larissa Stanberry, Ross Garberich, Steven M. Bradley, Robert Steffen, Paul Sorajja |
| Source: |
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-10 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Moderate, Aortic stenosis, Outcomes, Survival, Aortic valve replacement, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Background The natural history of patients with moderate aortic stenosis (AS) is poorly understood. We aimed to determine the long-term outcomes of patients with moderate AS. Methods We examined patients with moderate AS defined by echocardiography in our healthcare system, and performed survival analyses for occurrence of death, heart failure (HF) hospitalization, and progression of AS, with accounting for symptoms, left ventricular dysfunction, and comorbidities. Results We examined 729 patients with moderate AS (median age, 76 years; 59.9 % men) with a median follow-up of 5.0 years (interquartile range: 2.0 to 8.1 years). The 5-year overall survival was 52.3 % (95 % confidence interval [CI]: 48.6 % to 56.0 %) and survival free of death or HF hospitalization was 43.2 % (95 % CI: 39.5 % to 46.9 %). Worse New York Heart Association (NYHA) functional class was associated with poor long-term survival, with mortality rates ranging from 7.9 % (95 % CI: 6.6–9.2 %) to 25.2 % (95 % CI: 20.2–30.3 %) per year. Among patients with minimal or no symptoms, no futility markers, and preserved left ventricular function, 5-year overall survival was 71.9 % (95 % CI: 66.4–77.4 %) and survival free of death or HF hospitalization was 61.4 % (95 % CI: 55.5–67.3 %). Risk factors associated with adverse events were age, NYHA class, low ejection fraction and high aortic valve velocity (all p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2261 |
| Relation: |
https://doaj.org/toc/1471-2261 |
| DOI: |
10.1186/s12872-021-01901-1 |
| Access URL: |
https://doaj.org/article/8a7bfffcb82d4a9b8a83b2e790028a9b |
| Accession Number: |
edsdoj.8a7bfffcb82d4a9b8a83b2e790028a9b |
| Database: |
Directory of Open Access Journals |
