Bibliographic Details
| Title: |
Mutational status of RAS, SMAD4 and APC predicts survival after resection of colorectal liver metastases in Chinese patients: prognostic stratification based on genetic sequencing data of multiple somatic genes |
| Authors: |
Wen-Jia Chen, Hong-Wei Wang, Li-Jun Wang, Da Xu, Ming Liu, Bao-Cai Xing |
| Source: |
World Journal of Surgical Oncology, Vol 23, Iss 1, Pp 1-10 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Surgery
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Colorectal liver metastases, Liver resection, Multiple somatic genes, Prognostic stratification, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background This study aimed to investigate the impact of the mutational status of multiple genes on survival in Chinese patients with colorectal liver metastases (CRLM) undergoing liver resection. Methods This study included 519 Chinese patients undergoing curative liver resection for CRLM between 2011 and 2021 and had genomic sequencing data of 620 genes available for analysis. The genes associated with overall survival (OS) were identified using Cox regression analyses. The patients were stratified according to a novel scoring system based on the number of genes with a deleterious status (mutation or wild type), and OS was compared among the groups. The prognostic capacity of the scoring system was assessed using Harrell’s C-index. Results Twelve genes were mutated in more than 10% of the patients. RAS mutation, SMAD4 mutation, and APC wild-type status were significantly associated with worse OS. A scoring system was built based on the mutational status of RAS, SMAD4, and APC. Higher scores were significantly associated with worse OS (HR > 1, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1477-7819 |
| Relation: |
https://doaj.org/toc/1477-7819 |
| DOI: |
10.1186/s12957-025-03755-9 |
| Access URL: |
https://doaj.org/article/e8a7b8d043e94a9393791b6f300f1368 |
| Accession Number: |
edsdoj.8a7b8d043e94a9393791b6f300f1368 |
| Database: |
Directory of Open Access Journals |
