| Title: |
The human plasma lipidome response to exertional heat tolerance testing |
| Authors: |
Igor L. Estevao, Josh B. Kazman, Lisa M. Bramer, Carrie Nicora, Ming Qiang Ren, Nyamkhishig Sambuughin, Nathalie Munoz, Young-Mo Kim, Kent Bloodsworth, Maile Richert, Justin Teeguarden, Kristin Burnum-Johnson, Patricia A. Deuster, Ernesto S. Nakayasu, Gina Many |
| Source: |
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-12 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: |
Heat stress, Plasma lipidomics, Biomarkers, Heat tolerance testing, Physiological strain index, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: |
Abstract Background The year of 2023 displayed the highest average global temperatures since it has been recorded—the duration and severity of extreme heat are projected to increase. Rising global temperatures represent a major public health threat, especially to occupations exposed to hot environments, such as construction and agricultural workers, and first responders. Despite efforts of the scientific community, there is still a need to characterize the pathophysiological processes leading to heat related illness and develop biomarkers that can predict its onset. Methods Liquid chromatography-tandem mass spectrometry (LC–MS/MS)-based lipidomics analysis was performed on plasma from male and female subjects who underwent exertional heat tolerance testing (HTT), consisting of a 2-h treadmill walk at 5 km/h with 2.0% incline at a controlled temperature of 40ºC. From HTT, heat tolerance was calculated using the physiological strain index (PSI). Results Nearly half of all 995 detected lipids from 27 classes were responsive to HTT. Lipid classes related to substrate utilization were predominantly affected by HTT, with a downregulation of triacylglycerols and upregulation of free fatty acids and acyl-carnitines (CARs). Even chain CAR 4:0, 14:0 and 16:1, suggested by-products of incomplete beta oxidation, and diacylglycerols displayed the highest correlation to PSI. PSI did not correlate with plasma lactate levels, suggesting that correlations between even chain CARs and PSI are related to metabolic efficiency versus physical exertion. Conclusions Overall, HTT displays a strong impact on the human plasma lipidome and lipid metabolic inefficiencies may underlie reduced heat tolerance. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1476-511X |
| Relation: |
https://doaj.org/toc/1476-511X |
| DOI: |
10.1186/s12944-024-02322-7 |
| Access URL: |
https://doaj.org/article/aad8a64ea9334f3eb1e4e7e5fb9a25ea |
| Accession Number: |
edsdoj.8a64ea9334f3eb1e4e7e5fb9a25ea |
| Database: |
Directory of Open Access Journals |
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